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The safety profile is favorable

(1985) Pressor action and dipsogenicity induced by angiotensin II and III in rats

However, it does increase the risk of microbial growth

and biotechnology medications such as antitumor necrosis factor (TNF) agents, anti-interleukins, anti-integrins, and other newer agents with different targets and mechanisms of action

Especially when you have multiple systems, it is important to not have a system with a lot of downtime, unless proper disinfection and flushing procedures are done